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Penn Frontotemporal Degeneration Center



The Penn Frontotemporal Degeneration Center brings together an energetic team of creative clinicians and researchers dedicated to the investigation and treatment of early onset neurodegenerative conditions. Our team of experts include neurologists, neuropathologists, neuroscientists, geneticists, genetic counselors, neuropsychologists, nurses, social workers, and clinical research coordinators, all targeting a cure for Frontotemporal degeneration. 


The research expertise at the Penn FTD Center spans many levels of neuroscience ranging from detailed clinico-pathological studies, biomarker discovery, genetics, neuropsychological studies, functional and structural neuroimaging, and cognitive neuroscience investigations of language, memory, and social cognition. 


Volunteers who participate in Penn FTD Center research studies assist the Center in advancing the science of frontotemporal degenerative diseases and help us provide the highest quality of care for our clinical patients. 


To educate the community, both local and national, about young-onset dementias such as Frontotemporal degeneration, and; to increase local engagement and interest in research at the University of Pennsylvania Frontotemporal Degeneration Center (FTDC). These activities will help promote a community of support, access to resources, and improved outcomes for individuals with early onset-dementia and their families.​

Our Latest Publications

This study aimed to provide clinical validation for a set of automated vowel formant measures of spontaneous speech as markers of bulbar motor disease in ALS-FTSD by comparing ALS patients with bulbar impairment to spinal ALS patients without bulbar disease, bvFTD patients, the most common FTD syndrome in ALS-FTSD, and healthy controls; and relating vowel measures to bulbar symptom severity and listener effort.

Brain Scans
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