Jeffrey Phillips PhD
Research Assistant Professor
Dr. Jeffrey Phillips' research is driven by a desire to understand the progression of neurodegenerative disease and predict its effects at an individual patient level. His current research program includes a focus on atypical, earlier-onset variants of Alzheimer’s disease and on mixed pathologies. Methodologically, this work leverages MRI-based measures of grey and white matter degeneration (Phillips, Da Re, et al., 2018, 2019) as well as positron emission tomography (PET) imaging of tau protein accumulation to evaluate patients’ disease progression during life (Phillips et al., 2018, 2021). His long-term translational research plan is to develop quantitative, biomarker-based models of disease risk that link information from the molecular level (genotyping and pathology) to the systems level (structural, functional, and molecular neuroimaging) and overt behavior (neuropsychological and cognitive neuroscientific assessment). He aims to apply this research translationally to predict disease spread and cognitive changes on the individual patient level. By enhancing the diagnostic and prognostic value of antemortem imaging, we can more accurately target clinical care efforts and potential disease-modifying therapies.